Serotonergic innervation of the dorsal horn of rat spinal cord: light and electron microscopic immunocytochemical study
| Autor: | Michel Geffard, N. Rajaofetra, L. Marlier, Alain Privat, F. Sandillon, P. Poulat |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Serotonin Lamina Histology Central nervous system Biology Serotonergic Synaptic vesicle Immunoenzyme Techniques medicine Animals General Neuroscience Rats Inbred Strains Cell Biology Anatomy Spinal cord Immunohistochemistry Rats Microscopy Electron medicine.anatomical_structure Spinal Cord Synapses Ultrastructure Postsynaptic density |
| Zdroj: | Journal of Neurocytology. 20:310-322 |
| ISSN: | 1573-7381 0300-4864 |
| DOI: | 10.1007/bf01235548 |
| Popis: | The ultrastructure of serotonergic projections to the dorsal horn of the rat spinal cord has been investigated, using a highly specific polyclonal antiserum. The highest concentrations of immunoreactive profiles were found in lamina I and the outer part of lamina II (IIo). Intermediate concentrations were found in laminae III and IV, while the inner part of lamina II (IIi) was almost devoid of immunoreactivity. Whereas 60% of the profiles show at least one varicosity studded with synaptic vesicles, only one-fifth of the latter contributes to classical synapses, the remaining profiles being devoid of a facing postsynaptic density. The results are compared with those in the literature and our own results relative to other regions of the cord. It is concluded that the pauci-synaptic projections to the dorsal horn could correspond to a diffuse influence of serotonin, the targets for which are determined by the corresponding serotonergic receptors. |
| Databáze: | OpenAIRE |
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