An Integrated Clinical and Genetic Prediction Model for Tacrolimus Levels in Pediatric Solid Organ Transplant Recipients

Autor:	A. Nicole Lambert, Tom Blydt-Hansen, Noureddine Berka, Patricia Campbell, Sandar Min, Hartmut Grasemann, Simon Urschel, Kathryn Tinckham, Chee Loong Saw, Upton Allen, Tanya Papaz, Bethany J. Foster, Patricia E. Birk, Vicky L. Ng, Seema Mital, Sara L. Van Driest, Catherine Litalien, Rulan S. Parekh, Lorraine A. Hamiwka, Daniel Claude
Rok vydání:	2021
Předmět:	Oncology Linkage disequilibrium medicine.medical_specialty Adolescent Genotype medicine.medical_treatment Single-nucleotide polymorphism Genome-wide association study Polymorphism Single Nucleotide Tacrolimus Internal medicine Genetic model Cytochrome P-450 CYP3A Humans Medicine Prospective Studies Child Transplantation Dose-Response Relationship Drug business.industry Immunosuppression Organ Transplantation Transplant Recipients surgical procedures operative Cohort business Immunosuppressive Agents Genome-Wide Association Study Cohort study
Zdroj:	Transplantation. 106:597-606
ISSN:	0041-1337
DOI:	10.1097/tp.0000000000003700
Popis:	BACKGROUND There are challenges in achieving and maintaining therapeutic tacrolimus levels after solid organ transplantation (SOT). The purpose of this genome-wide association study (GWAS) was to generate an integrated clinical and genetic prediction model for tacrolimus levels in pediatric SOT. METHODS In a multicenter prospective observational cohort study (2015-18), children
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d318bc8e28fdb329f8f5dd05624c26 https://doi.org/10.1097/tp.0000000000003700 Zobrazit plný text záznamu