Multi-delay multi-parametric arterial spin-labeled perfusion MRI in acute ischemic stroke — Comparison with dynamic susceptibility contrast enhanced perfusion imaging
| Autor: | Jeffrey L. Saver, Danny J.J. Wang, Jeffry R. Alger, Noriko Salamon, Joe X Qiao, Whitney B. Pope, Matthias Günther, David S Liebeskind |
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| Jazyk: | angličtina |
| Předmět: |
Cognitive Neuroscience
Ischemia Multi-delay Perfusion scanning Article medicine.artery Medicine Acute stroke Multi-parametric Radiology Nuclear Medicine and imaging Stroke business.industry medicine.disease Neurology Cerebral blood flow Middle cerebral artery Spin echo Perfusion MRI Neurology (clinical) Dynamic susceptibility contrast (DSC) business Nuclear medicine Perfusion Arterial spin labeling (ASL) Diffusion MRI |
| Zdroj: | Wang, DJJ; Alger, JR; Qiao, JX; Gunther, M; Pope, WB; Saver, JL; et al.(2013). Multi-delay multi-parametric arterial spin-labeled perfusion MRI in acute ischemic stroke-Comparison with dynamic susceptibility contrast enhanced perfusion imaging. NeuroImage: Clinical, 3, 1-7. doi: 10.1016/j.nicl.2013.06.017. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4rd328h1 NeuroImage : Clinical |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2013.06.017 |
| Popis: | The purpose of the present study was to present a multi-delay multi-parametric pseudo-continuous arterial spin labeling (pCASL) protocol with background suppressed 3D GRASE (gradient and spin echo) readout for perfusion imaging in acute ischemic stroke. PCASL data at 4 post-labeling delay times (PLD = 1.5, 2, 2.5, 3 s) were acquired within 4.5 min in 24 patients (mean age 79.7 ± 11.4 years; 11 men) with acute middle cerebral artery (MCA) stroke who also underwent dynamic susceptibility contrast (DSC) enhanced perfusion imaging. Arterial transit times (ATT) were estimated through the calculation of weighted delays across the 4 PLDs, which were included in the calculation of cerebral blood flow (CBF) and arterial cerebral blood volume (CBV). Mean perfusion parameters derived using pCASL and DSC were measured within MCA territories and infarct regions identified on diffusion weighted MRI. The results showed highly significant correlations between pCASL and DSC CBF measurements (r > = 0.70, p = 0.45, p Graphical abstract Comparison of multi-parametric ASL and DSC perfusion images along with FLAIR and DWI in a representative stroke case (89 year-old female). ASL shows decreased CBF, decreased CBV and prolonged ATT in the left MCA region. DSC Tmax and MTT are prolonged in the left frontal region with mildly decreased CBF and CBV. Highlights • A multi-delay multi-parametric pCASL GRASE protocol was developed. • The pCASL protocol showed consistent results with DSC perfusion MRI in acute stroke patients. • The capability for multi-parametric perfusion imaging using ASL offers numerous potentials. |
| Databáze: | OpenAIRE |
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