Cerebral Na concentration, Na appetite and thirst of sheep: influence of somatostatin and losartan
Autor: | B. Purcell, R. S. Weisinger, J. R. Blair-West, Peta Burns, Derek A. Denton |
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Rok vydání: | 2001 |
Předmět: |
medicine.medical_specialty
Physiology media_common.quotation_subject Hypertonic Solutions Drinking Appetite Receptor Angiotensin Type 2 Losartan Receptor Angiotensin Type 1 Thirst Angiotensin Receptor Antagonists Physiology (medical) Internal medicine medicine Animals Mannitol media_common computer.programming_language Saline Solution Hypertonic Sheep Chemistry sed Angiotensin II digestive oral and skin physiology Sodium Brain Sodium Dietary Somatostatin Endocrinology Tonicity Female medicine.symptom computer hormones hormone substitutes and hormone antagonists medicine.drug |
Zdroj: | Scopus-Elsevier |
ISSN: | 0363-6119 |
Popis: | Na and water intakes of Na-depleted sheep are influenced by changes in cerebral Na concentration. The effect of intracerebroventricular infusion of somatostatin or losartan, the ANG II type 1 receptor antagonist, on the Na appetite and thirst of Na-depleted sheep during infusions that decrease (intracerebroventricular hypertonic mannitol) or increase (intracerebroventricular or systemic hypertonic NaCl) cerebral Na concentration was investigated. Na intake was increased but water intake was unchanged during intracerebroventricular infusion of hypertonic mannitol. The increased Na appetite caused by intracerebroventricular infusion of hypertonic mannitol was decreased by concurrent intracerebroventricular infusion of either somatostatin or losartan, with somatostatin being most effective. Water intake was increased during intracerebroventricular infusion of hypertonic mannitol and somatostatin. Na intake was decreased and water intake was increased during systemic or intracerebroventricular infusion of hypertonic NaCl. Intracerebroventricular infusion of losartan blocked both (Na and water intake), whereas somatostatin did not influence either of these changes in intake. The results further consolidate a role for somatostatin and ANG II in the central mechanisms controlling Na appetite and thirst of sheep. |
Databáze: | OpenAIRE |
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