Benzodiazepines and antidepressants: Effects on cognitive and functional decline in Alzheimer's disease and Lewy body dementia
| Autor: | Miguel Germán Borda, Diego Alejandro Tovar-Rios, Ragnhild Oesterhus, Carlos Cano-Gutierrez, Hogne Soennesyn, Jose Manuel Santacruz, Dag Aarsland, Audun Osland Vik-Mo, Alberto Jaramillo-Jimenez |
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| Rok vydání: | 2021 |
| Předmět: |
Lewy Body Disease
medicine.medical_specialty Activities of daily living Functional disability Cognitive decline Cohort Studies Benzodiazepines Cognition Alzheimer Disease Medisinske Fag: 700 [VDP] medicine Humans Dementia Case-control method Medical prescription Psychiatry Aged Lewy body Norway business.industry Hypnotics and sedatives Disability Rating Scale Alzheimer's disease medicine.disease Antidepressive Agents Estudio caso-control Psychiatry and Mental health Antidepressive Agent Lewy body dementia Geriatrics and Gerontology business Cohort study |
| Zdroj: | International Journal of Geriatric Psychiatry RED: Repositorio Educativo Digital UAO Universidad Autónoma de Occidente instacron:Universidad Autónoma de Occidente |
| ISSN: | 1099-1166 0885-6230 |
| DOI: | 10.1002/gps.5494 |
| Popis: | Objectives We aim to study the effects of the prescription of benzodiazepines and antidepressants on cognitive and functional decline in older adults living with AD (Alzheimer's disease) and LBD (Lewy body dementia) over a five-year follow-up. Methods This is a longitudinal analysis of a Norwegian cohort study entitled "The Dementia Study of Western Norway" (DemVest). We included 196 patients newly diagnosed with AD (n=111) and LBD (n=85), followed annually for 5 years. 3 prescription groups were defined: only benzodiazepines (BZD), only antidepressants (ADep), and the combination of benzodiazepines and antidepressants (BZD-ADep). Linear mixed-effects models were conducted to analyze the effect of the defined groups on the outcomes. The outcomes were functional decline, measured by the Rapid Disability Rating Scale - 2, and cognition measured with the Mini-Mental State Examination. Results Prescription of the combination of benzodiazepines and antidepressants in LBD was associated with faster functional decline. In AD, the prescription of BZD and BZD-ADep was associated with greater functional deterioration. ADep alone didn't show positive or negative significant associations with the studied outcomes. Conclusions BZD and especially the combination of BZD and ADep are associated with functional decline in AD and LBD and should be used cautiously. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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