Upregulation of miR-128 Mediates Heart Injury by Activating Wnt/β-catenin Signaling Pathway in Heart Failure Mice

Autor:	Jing-Yao Li, Xin-Chang Li, Yu-Long Tang
Rok vydání:	2021
Předmět:	Heart Failure Transplantation Embryology Mice MicroRNAs Heart Injuries Biomedical Engineering Animals Humans Wnt Signaling Pathway Developmental Biology Up-Regulation
Zdroj:	Organogenesis. 17(3-4)
ISSN:	1555-8592
Popis:	Cardiac hypertrophy contributes to heart failure and is pathogenically modulated by a network of signaling cascades including Wnt/β-catenin signaling pathway. miRNAs have been widely demonstrated to regulate gene expression in heart development. miR-128 was routinely found as a brain-enriched gene and has been functionally associated with regulation of cardiac function. However, its role and molecular mechanisms that regulate cardiac hypertrophy remain largely unclear. Adeno-associated virus serotype 9 (AAV9)-mediated constructs with miR-128 or anti-miR-128 were generated and delivered to overexpression or blockade of miR-128
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c8e145dd0d2939f177f7198ac3a225 https://pubmed.ncbi.nlm.nih.gov/34965835 Zobrazit plný text záznamu