Pax3/Pax7 mark a novel population of primitive myogenic cells during development
| Autor: | Lina Kassar-Duchossoy, Shahragim Tajbakhsh, Ellen Giacone, Barbara Gayraud-Morel, Aurélie Jory, Danielle Gomès |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Myoblasts
Skeletal Population PAX3 Apoptosis Mice Transgenic Biology Cell fate determination Muscle Development Research Communications Mice Genetics medicine Animals Paired Box Transcription Factors Myocyte Progenitor cell Muscle Skeletal education PAX3 Transcription Factor Homeodomain Proteins Mice Knockout education.field_of_study Gene Expression Regulation Developmental PAX7 Transcription Factor Skeletal muscle musculoskeletal system Molecular biology Cell biology DNA-Binding Proteins Somite medicine.anatomical_structure Myogenic regulatory factors Biomarkers Transcription Factors Developmental Biology |
| Zdroj: | Genes & Development. 19:1426-1431 |
| ISSN: | 1549-5477 0890-9369 |
| DOI: | 10.1101/gad.345505 |
| Popis: | Skeletal muscle serves as a paradigm for the acquisition of cell fate, yet the relationship between primitive cell populations and emerging myoblasts has remained elusive. We identify a novel population of resident Pax3+/Pax7+, muscle marker-negative cells throughout development. Using mouse mutants that uncouple myogenic progression, we show that these Pax+ cells give rise to muscle progenitors. In the absence of skeletal muscle, they apoptose after down-regulation of Pax7. Furthermore, they mark the emergence of satellite cells during fetal development, and do not require Pax3 function. These findings identify critical cell populations during lineage restriction, and provide a framework for defining myogenic cell states for therapeutic studies. |
| Databáze: | OpenAIRE |
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