Green synthesis of 2-pyrazinones in deep eutectic solvents: From α-chloro oximes to peptidomimetic scaffolds
| Autor: | Francesco Messa, Serena Perrone, Martina Capua, Luigino Troisi, Antonio Salomone |
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| Přispěvatelé: | Perrone, Serena, Capua, Martina, Messa, Francesco, Salomone, Antonio, Troisi, Luigino |
| Rok vydání: | 2017 |
| Předmět: |
Deep eutectic solvent
Reaction conditions Peptidomimetic 010405 organic chemistry Chemistry α-Chloro oxime Drug Discovery3003 Pharmaceutical Science Organic Chemistry 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound 2-Pyrazinone Green chemistry Drug Discovery Organic chemistry Eutectic system Choline chloride |
| Zdroj: | Tetrahedron. 73:6193-6198 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2017.09.013 |
| Popis: | A novel and green synthesis of 2-pyrazinones in deep eutectic solvents (DESs) is described. Treatment of aromatic α-chloro oximes with aliphatic amines at 110 °C in choline chloride based DESs resulted in a straightforward and efficient assembly of 1,3,5-trisubstituted-2(1H)-pyrazinones. The protocol, featuring mild reaction conditions and avoiding common volatile organic solvents, affords a safe and sustainable approach to original peptidomimetic scaffolds. |
| Databáze: | OpenAIRE |
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