Idiopathic Aneurysms of the Ascending Aorta in the Mouse and Rat
| Autor: | Ahamat Aboulmali, Bethany Balmer, Daniel Petkov, Alys Bradley, Daniel J. Patrick, Paul C. Howroyd, Petrina Rogerson, Gayle Hennig, Melissa Czajkowski, David A Rehagen, Joshua H. Decker |
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| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Inflammation Toxicology Pathology and Forensic Medicine Pathogenesis Mice Aneurysm medicine.artery Adventitia Ascending aorta medicine Animals Molecular Biology Aorta Aortic Aneurysm Thoracic business.industry Nonclinical safety Cell Biology medicine.disease Rats medicine.anatomical_structure cardiovascular system Macroscopic Findings medicine.symptom business Dilatation Pathologic |
| Zdroj: | Toxicologic Pathology. 50:4-12 |
| ISSN: | 1533-1601 0192-6233 |
| DOI: | 10.1177/01926233211056872 |
| Popis: | Aneurysms of the ascending aorta, unrelated to xenobiotic administration, are described in 5 rats and 2 mice in nonclinical safety studies conducted at Charles River Laboratories (CRL) sites over the past 10 years. The most prominent microscopic finding was focal dilation with disruption of the wall of the ascending aorta with chronic adventitial inflammation or fibroplasia. The pathogenesis of this finding is unknown. There were no associated macroscopic findings, clinical abnormalities, or vascular lesions elsewhere. The results of a search of historical control data from toxicology studies of 1 day to 72 weeks’ duration performed at CRL for aortic findings from 5900 mice and 23,662 rats are also reported. Aortic lesions are uncommon in mice and rats used in nonclinical safety studies, but toxicologic pathologists should be aware that aneurysms of the ascending aorta with fibroplasia and inflammation in the aortic wall and adventitia may occur spontaneously or iatrogenically, as they have the potential to impact interpretation in toxicology studies. |
| Databáze: | OpenAIRE |
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