Genetic susceptibility, obesity and lifetime risk of type 2 diabetes
| Autor: | Alanna C. Morrison, James S. Pankow, M. Arfan Ikram, Abbas Dehghan, Maarten J.G. Leening, Symen Ligthart, Natalie R Hasbani, Eric J.G. Sijbrands, Paul S. de Vries, Maryam Kavousi, André G. Uitterlinden, Elizabeth Selvin, Eric Boerwinkle, Fariba Ahmadizar, Thijs T. W. van Herpt |
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| Přispěvatelé: | Intensive Care, Epidemiology, Internal Medicine, Cardiology |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Risk Multifactorial Inheritance Endocrinology Diabetes and Metabolism Population Type 2 diabetes Article White People Rotterdam Study Endocrinology SDG 3 - Good Health and Well-being Diabetes mellitus Internal Medicine medicine Genetic predisposition Humans Genetic Predisposition to Disease Obesity education Aric study Life Style Aged education.field_of_study business.industry Genetic Variation Middle Aged medicine.disease Diabetes Mellitus Type 2 Lifetime risk Female business Demography |
| Zdroj: | Diabet Med Diabetic Medicine, 38(10):e14639. Wiley-Blackwell Publishing Ltd |
| ISSN: | 1464-5491 0742-3071 |
| Popis: | Aims: Both lifestyle factors and genetic background contribute to the development of type 2 diabetes. Estimation of the lifetime risk of diabetes based on genetic information has not been presented, and the extent to which a normal body weight can offset a high lifetime genetic risk is unknown. Methods: We used data from 15,671 diabetes-free participants of European ancestry aged 45 years and older from the prospective population-based ARIC study and Rotterdam Study (RS). We quantified the remaining lifetime risk of diabetes stratified by genetic risk and quantified the effect of normal weight in terms of relative and lifetime risks in low, intermediate and high genetic risk. Results: At age 45 years, the lifetime risk of type 2 diabetes in ARIC in the low, intermediate and high genetic risk category was 33.2%, 41.3% and 47.2%, and in RS 22.8%, 30.6% and 35.5% respectively. The absolute lifetime risk for individuals with normal weight compared to individuals with obesity was 24% lower in ARIC and 8.6% lower in RS in the low genetic risk group, 36.3% lower in ARIC and 31.3% lower in RS in the intermediate genetic risk group, and 25.0% lower in ARIC and 29.4% lower in RS in the high genetic risk group. Conclusions: Genetic variants for type 2 diabetes have value in estimating the lifetime risk of type 2 diabetes. Normal weight mitigates partly the deleterious effect of high genetic risk. |
| Databáze: | OpenAIRE |
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