Whole blood haemostatic function throughout a 28‐day cold storage period: an in vitro study
| Autor: | Hannah L McRae, Neil Blumberg, Christine Cahill, Chelsea Milito, Majed A. Refaai, Ferhat Kara |
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| Rok vydání: | 2020 |
| Předmět: |
Blood Platelets
Cold storage 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Refrigeration Free haemoglobin Humans In vitro study Medicine Blood Transfusion Platelet Whole blood Hemostasis medicine.diagnostic_test Platelet Count business.industry Complete blood count Hematology General Medicine Haemostatic function Thromboelastography Blood Cell Count Thrombelastography Blood Preservation Anesthesia business 030215 immunology |
| Zdroj: | Vox Sanguinis. 116:190-196 |
| ISSN: | 1423-0410 0042-9007 |
| Popis: | BACKGROUND In recent years, there has been renewed interest in whole blood (WB) transfusion, particularly in damage control resuscitation, in part due to the ability to provide the adequate ratio of blood components in a single transfusion. However, there is insufficient evidence to suggest that WB units maintain their haemostatic function during storage, which could compromise their quality and efficacy if transfused. Here, we evaluate the in vitro haemostatic function of stored WB units over a 28-day refrigeration period. METHODS Standard WB units were collected from healthy volunteers and stored at 4°C for 28 days. Samples were collected from each unit on several days throughout the storage period and tested for complete blood count (CBC), WB aggregation, clot kinetics as measured by thromboelastography (TEG), closure time and plasma-free haemoglobin. RESULTS Throughout the storage period, there were gradual, significant decreases in platelet count and function, including WB aggregation in response to collagen (P |
| Databáze: | OpenAIRE |
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