Remarkable Levels of 15N Polarization Delivered through SABRE Into Unlabeled Pyridine, Pyrazine or Metronidazole Enable Single Scan NMR Quantification at the mM Level
| Autor: | Simon B. Duckett, Fadi Ahwal, Marianna Fekete |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
010304 chemical physics
Pyrazine Analytical chemistry chemistry.chemical_element 010402 general chemistry Spin isomers of hydrogen Polarization (waves) 01 natural sciences Article 3. Good health 0104 chemical sciences Surfaces Coatings and Films chemistry.chemical_compound chemistry Reagent 0103 physical sciences Pyridine Materials Chemistry Iridium Single scan Physical and Theoretical Chemistry Acetonitrile |
| Zdroj: | The Journal of Physical Chemistry. B |
| ISSN: | 1520-5207 |
| Popis: | While many drugs and metabolites contain nitrogen, harnessing their diagnostic 15N NMR signature for their characterization is underutilized because of inherent detection difficulties. Here, we demonstrate how precise ultralow field signal amplification by reversible exchange (±0.2 mG) in conjunction parahydrogen and an iridium precatalyst of the form IrCl(COD)(NHC) with the coligand d9-benzylamine allows the naturally abundant 15N NMR signatures of pyridine, pyrazine, metronidazole, and acetonitrile to be readily detected at 9.4 T in single NMR observations through >50% 15N polarization levels. These signals allow for rapid and precise reagent quantification via a response that varies linearly over the 2-70 mM concentration range. |
| Databáze: | OpenAIRE |
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