Characterization of the genomic organization of human carcinoembryonic antigen (CEA): Comparison with other family members and sequence analysis of 5′ controlling region
| Autor: | T.C. Willcocks, Ian W. Craig |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Sequence analysis
Molecular Sequence Data Homology (biology) Exon Carcinoembryonic antigen Sequence Homology Nucleic Acid Genetics Humans Coding region Amino Acid Sequence Promoter Regions Genetic Gene Repetitive Sequences Nucleic Acid Genomic organization Base Sequence biology DNA Cosmids Carcinoembryonic Antigen Enhancer Elements Genetic Gene Expression Regulation Genes Multigene Family biology.protein Cosmid |
| Zdroj: | Genomics. 8:492-500 |
| ISSN: | 0888-7543 |
| Popis: | A cosmid containing the entire coding region for human carcinoembryonic antigen has been isolated. Detailed analysis and sequencing have determined an organization comprising nine exons encoding amino acids and one for a 3′ untranslated fragment. Comparison with other family members reveals a complex pattern of homology at the 3′ end of the gene. The 5′ noncoding region is rich in purinerich motifs and possible enhancer elements and has a region with properties similar to those of HTF islands. |
| Databáze: | OpenAIRE |
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