Expansion of the peri-implant attached gingiva with a three-dimensional collagen matrix in head and neck cancer patients-results from a prospective clinical and histological study
| Autor: | Robert Sader, A. Teiler, Mike Barbeck, C. James Kirkpatrick, Shahram Ghanaati, Maximilian Blume, Jonas Lorenz |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Peri Gingiva Dentistry Connective tissue 02 engineering and technology Matrix (biology) 03 medical and health sciences 0302 clinical medicine Germany Medicine Humans Prospective Studies Vestibuloplasty Prospective cohort study General Dentistry Aged Dental Implants business.industry Head and neck cancer 030206 dentistry Middle Aged 021001 nanoscience & nanotechnology medicine.disease Epithelium stomatognathic diseases medicine.anatomical_structure Head and Neck Neoplasms Female Implant Collagen 0210 nano-technology business |
| Zdroj: | Clinical oral investigations. 21(4) |
| ISSN: | 1436-3771 |
| Popis: | Attached peri-implant gingiva has proven to have an influence on the long-term stability of dental implants. In patients with head and neck cancer, a functional peri-implant gingiva is even more of critical importance. The aim of the presented prospective study was to investigate a three-dimensional xenogeneic collagen matrix for augmentation around dental implants in patients with former head and neck cancer. Eight patients presenting with insufficient peri-implant gingiva underwent vestibuloplasty on 51 implants using a xenogeneic collagen matrix. The clinical performance and the shrinking tendency of the matrix were analyzed in a cohort study. Furthermore, eight biopsies from the augmented regions were examined histologically to determine the biomaterial-related tissue reaction. Initially after vestibuloplasty, a mean width of attached gingiva of 4.4 ± 0.94 mm could be achieved. At clinical follow up investigation 6 months after vestibuloplasty, a mean width of 3.9 ± 0.65 mm attached peri-implant gingiva with a mean shrinking tendency of 14 % could be detected. Histological analysis of the biopsies revealed a well integrated collagen22 matrix covered with epithelium. Within the compact layer, mononuclear cells were observed only, while the spongious layer was infiltrated with a cell-rich connective tissue. Within its limits, the presented study revealed that the investigated collagen matrix is suitable to enlarge the peri-implant attached gingiva in head and neck cancer patients without adverse reactions or a multinucleated giant cell-triggered tissue reaction. The application of the investigated three-dimensional collagen matrix in vestibuloplasty achieved a sufficient amount of peri-implant attached gingiva in head and neck cancer patients. The favorable tissue reaction and the low shrinking tendency make the collagen matrix a promising alternative to autologous tissue grafts. |
| Databáze: | OpenAIRE |
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