Development of an oral prime–boost strategy to elicit broadly neutralizing antibodies against HIV-1
| Autor: | George K. Lewis, Roberta Kamin-Lewis, Mohamed T. Shata, Timothy R. Fouts, Anthony L. DeVico, David M. Hone |
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| Rok vydání: | 2002 |
| Předmět: |
Models
Molecular Salmonella typhimurium Cellular immunity Receptors CCR5 Protein Conformation Recombinant Fusion Proteins Immunization Secondary Administration Oral CD8-Positive T-Lymphocytes HIV Antibodies HIV Envelope Protein gp120 Biology Vaccines Attenuated Virus Shigella flexneri DNA vaccination Mice Immunity Protein Interaction Mapping Vaccines DNA Animals Humans Immunity Mucosal AIDS Vaccines General Veterinary General Immunology and Microbiology Vaccination Public Health Environmental and Occupational Health Salmonella typhi biology.organism_classification Macaca mulatta Virology Protein Structure Tertiary Infectious Diseases Immunization Bacterial Vaccines CD4 Antigens Immunology Humoral immunity Lentivirus HIV-1 Molecular Medicine |
| Zdroj: | Vaccine. 20:1968-1974 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/s0264-410x(02)00080-4 |
| Popis: | Given the increasing incidence of HIV-1 infection world-wide, an affordable, effective vaccine is probably the only way that this virus will be contained. Accordingly, our group is developing an oral prime–boost strategy with the primary goal of eliciting broadly neutralizing antibodies against HIV-1 to provide sterilizing immunity for this virus. Our secondary goal is to elicit broadly cross-reactive anti-viral CD8 + T cells by this strategy to blunt any breakthrough infections that occur after vaccination of individuals who fail to develop sterilizing immunity. This article describes our progress in the use of the live attenuated intracellular bacteria, Salmonella and Shigella , as oral delivery vehicles for DNA vaccines and the development of conformationally constrained HIV-1 Env immunogens that elicit broadly neutralizing antibodies. |
| Databáze: | OpenAIRE |
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