Congenital heart disease in Down syndrome – A review of temporal changes
| Autor: | Ellen Hollands Steffensen, Stephanie L. Santoro |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
endocardial cushion defect
Research design lcsh:Diseases of the circulatory (Cardiovascular) system congenital heart malformation Pediatrics Trisomy 21 Future studies Heart disease Down syndrome heart disease lung vein drainage anomaly 030204 cardiovascular system & hematology physical examination great vessels transposition 0302 clinical medicine echocardiography thorax radiography medicine.diagnostic_test Confounding General Medicine fetus malformation tricuspid valve atresia congenital heart disease priority journal cardiovascular malformation disease severity Cardiac survival rate medicine.medical_specialty Eisenmenger complex prevalence Cardiology disease classification review Physical examination electrocardiogram External validity patent ductus arteriosus 03 medical and health sciences heart ventricle septum defect 030225 pediatrics medicine human Internal validity Ebstein anomaly heart single ventricle Congenital heart disease business.industry pulmonary valve atresia screening medicine.disease fetus death lcsh:RC666-701 heart right ventricle double outlet Fallot tetralogy heart atrium septum defect business |
| Zdroj: | Santoro, S L & Steffensen, E H 2021, ' Congenital heart disease in Down syndrome – A review of temporal changes ', Journal of Congenital Cardiology, vol. 5, no. 1, 1 . https://doi.org/10.1186/s40949-020-00055-7 Journal of Congenital Cardiology, Vol 5, Iss 1, Pp 1-14 (2021) |
| ISSN: | 2056-7251 |
| DOI: | 10.1186/s40949-020-00055-7 |
| Popis: | BackgroundCongenital heart disease (CHD) is a well-known co-occurring condition in Down syndrome (DS). We aimed to review the literature to evaluate the current evidence to address key questions.MethodsA series of key questions were formulated a priori to inform the search strategy and review process. These addressed the topics of prevalence, type of CHD, severity, and screening. Using the National Library of Medicine database, PubMed, detailed literature searches were performed. The quality of available evidence was then evaluated, the existing literature was summarized, and knowledge gaps were identified.ResultsFifty-six relevant original articles were identified which addressed at least one key question. Study details, including: research design, internal validity, external validity, and relevant results are presented. The total prevalence of CHD reported in DS ranged from 20 to 57.9%. In later decades, the prevalence remained constant at 40—55%. The types and classification of CHD varied considerably between studies. Some studies indicate a trend towards a milder phenotype, but this was not consistent. Over time, some studies observed an improved prognosis for CHD in DS. Studies investigating screening for CHD by physical examination, chest X-ray, and electrocardiogram report sensitivities of 71–95%.ConclusionTo further improve knowledge on CHD in DS, we suggest that future studies cover a wide range of nations and regions, with a longitudinal design, and account for potential confounding factors. |
| Databáze: | OpenAIRE |
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