An outbreak of systemic granulomatous disease in cows with high milk yields
| Autor: | Osamu Fukuda, Makoto Haritani, Atsuko Hagiwara, Shigeru Miyazaki, Mitsuo Shiono, Katsuhiko Fukai, Ayako Iizuka, Toshiya Saito, Mitsuo Sato, Kumiko Kimura, Takashi Takahashi, Kyoko Nakazawa, Nobuhiko Tanimura, Masaru Kobayashi |
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| Rok vydání: | 2005 |
| Předmět: |
Pathology
medicine.medical_specialty Citrus T-Lymphocytes Cattle Diseases Spleen Inflammation Kidney Giant Cells Disease Outbreaks Japan medicine Macrophage Animals Plant Poisoning Granuloma Hematologic Tests General Veterinary Adrenal gland business.industry food and beverages Hyperplasia medicine.disease Immunohistochemistry medicine.anatomical_structure Giant cell Cattle Female Lymph medicine.symptom Pancreas business |
| Zdroj: | The Journal of veterinary medical science. 67(7) |
| ISSN: | 0916-7250 |
| Popis: | Seven of 92 lactating Holstein cows on a dairy farm developed urticaria with alopecia and decreased milk production, and three of the seven died over the course of 7 to 18 days. Pathologic examination of the three cows, including the two dead and one euthanized cow, revealed that the skin, liver, spleen, kidneys, heart, salivary glands, pancreas, adrenal glands, mammary glands, lymph nodes, and trigeminal ganglia had lymphocytic to lymphogranulomatous inflammation. Inflammation predominated by lymphocytic infiltration was prominent in the heart, pancreas, mammary glands, adrenal gland, and trigeminal ganglia. Severe granulomatous inflammation with multinucleated giant cells was present in the spleen and kidneys. These lesions and their distributions were most similar to those seen in suspected cases of citrus pulp toxicosis and hairy vetch toxicosis. The outbreak of this disease resolved with the elimination of Citrus pulp from the feed. Immunohistochemical detection of lymphocytes and macrophage markers confirmed dramatic hyperplasia of CD3-positive T lymphocytes in these lesions. This strongly suggested that a type 4 hypersensitivity reaction played a role in the development of the lesions. |
| Databáze: | OpenAIRE |
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