Antimalarial Bromotyrosine Derivatives from the Australian Marine Sponge Hyattella sp
| Autor: | Rohan A. Davis, David Brian Camp, Sandra Duffy, Xinzhou Yang, Vicky M. Avery, Malcolm Stewart Buchanan, Ronald J. Quinn |
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| Rok vydání: | 2010 |
| Předmět: |
Plasmodium falciparum
Pharmaceutical Science Marine Biology Drug resistance Analytical Chemistry Microbiology Antimalarials chemistry.chemical_compound Alkaloids Parasitic Sensitivity Tests parasitic diseases Drug Discovery Animals Parasite hosting Psammaplysin F Pharmacology Natural product Dose-Response Relationship Drug Molecular Structure biology Drug discovery Alkaloid Organic Chemistry Australia Chloroquine biology.organism_classification Hydrocarbons Brominated Porifera Sponge Complementary and alternative medicine chemistry Tyrosine Molecular Medicine |
| Zdroj: | Journal of Natural Products. 73:985-987 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np900834g |
| Popis: | A drug discovery program aimed at identifying new antimalarial leads from a prefractionated natural product library has resulted in the identification of a new bromotyrosine alkaloid, psammaplysin G (1), along with the previously isolated compound, psammaplysin F (2). When tested against two different strains of the parasite Plasmodium falciparum (Dd2 and 3D7), 2 displayed IC(50) values of 1.4 and 0.87 microM, respectively, while 1 showed 98% inhibition at 40 microM against the chloroquine-resistant (Dd2) strain of P. falciparum. |
| Databáze: | OpenAIRE |
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