Low serum 25‐hydroxyvitamin D3 levels and late delayed radiation‐induced brain injury in patients with nasopharyngeal carcinoma: A case–control study
| Autor: | Xurui Huang, Haiwei Huang, Junjie Guo, Zhezhi Deng, Minping Li, Yongxin Huang, Dongxiao Zhou |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Radiation induced Gastroenterology 050105 experimental psychology lcsh:RC321-571 Pathogenesis 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Cerebrospinal fluid Internal medicine Vitamin D and neurology Humans Medicine 0501 psychology and cognitive sciences In patient Vitamin D radiation‐induced brain injury lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Calcifediol Original Research Nasopharyngeal Carcinoma business.industry 05 social sciences Case-control study Nasopharyngeal Neoplasms medicine.disease 25‐hydroxyvitamin D3 immune inflammatory effects Nasopharyngeal carcinoma Brain Injuries Case-Control Studies Biomarker (medicine) biomarker Female business 030217 neurology & neurosurgery |
| Zdroj: | Brain and Behavior, Vol 10, Iss 12, Pp n/a-n/a (2020) Brain and Behavior |
| ISSN: | 2162-3279 |
| Popis: | Background and Purpose Inflammatory reaction plays a critical role in the pathogenesis of late delayed radiation‐induced brain injury (RBI). Low vitamin D levels are closely associated with various immuno‐inflammatory diseases, but the relationship with late delayed RBI remains unknown. Here, we aimed to determine the association of serum vitamin D levels with clinical parameters in late delayed RBI patients with nasopharyngeal carcinoma. Methods 25‐Hydroxyvitamin D3 levels and clinical and cerebrospinal fluid parameters were evaluated in 21 patients with RBI and compared with 90 age‐, sex‐, and season‐matched healthy controls. Results 25‐(OH)D3 levels were lower in patients with RBI compared to controls (40.39 ± 22.11 vs. 64.54 ± 19.89 nmol/L, p Inflammatory reaction plays a critical role in the pathogenesis of RBI. Low vitamin D levels are closely associated with various immuno‐inflammatory diseases, but the relationship with late delayed RBI remains unknown. Here, we reported that patients with RBI had significantly lower serum levels of 25(OH)D3 than age‐, season‐ and sex‐matched control subjects. Furthermore, low levels of 25(OH)D3 were associated with female sex, older age, short latency, and disease disability. |
| Databáze: | OpenAIRE |
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