Effect of thyroid hormone on concentrations of plasma calcitonin in broiler chicks
| Autor: | H. Klandorf, John Killefer, S.B. Holt, M. Iqbal, D.R. Deaver, R.A. Peterson, C.S. Boyce |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Calcitonin
medicine.medical_specialty Aging medicine.medical_treatment Immunology Thyroid Gland Antithyroid Agents Internal medicine Medicine Animals Goitrogen Saline Pharmacology Triiodothyronine Methimazole business.industry Antithyroid agent Thyroid Body Weight Thyroidectomy Organ Size Thyroxine medicine.anatomical_structure Endocrinology Calcium Female business Chickens Hormone |
| Zdroj: | Comparative biochemistry and physiology. Part C, Pharmacology, toxicologyendocrinology. 122(1) |
| ISSN: | 1367-8280 |
| Popis: | The purpose of these studies was to determine the effect of thyroidectomy (Tx), and thyroid hormone (T 3 /T 4 ) treatment on concentrations of plasma CT in chicks. In addition, the turnover of CT in Tx- and T 3 /T 4 -treated chicks was estimated using a novel nonradioactive salmon CT preparation. One-week-old broiler chicks ( Gallus domesticus ) ( n =75) were divided into three groups. Group I was sham-injected daily (i.m. saline), Group II was injected with 50 μ g/day of T 3 /T 4 while Group III was injected with the goitrogen, methimazole, (150 mg/kg BW per day) for 8 weeks. Chicks (8–9 weeks old) were implanted with catheters in the brachial wing vein and administered ruthenium-labeled salmon CT. Blood samples were collected at 30 s, 1, 2, 4, 8, 20 min, and 3 h after injection. Results showed that concentrations of plasma CT were decreased in T 3 /T 4 -injected birds. There was no significant effect of methimazole on circulating concentrations of plasma CT. The half-life of CT was significantly increased ( P 3 /T 4 -injected ( n =6; 1.34±0.16 min) and goitrogen-treated birds ( n =2; 5.81±2.83 min) compared to controls ( n =7; 54±3 s) The results demonstrate that changes in concentrations of plasma thyroid hormones can significantly affect concentrations of plasma CT. |
| Databáze: | OpenAIRE |
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