Immunohistochemical analysis of dichloroacetic acid (DCA)-induced hepatocarcinogenesis in male Fischer (F344) rats
| Autor: | Harry W. Carter, F B Daniel, Anthony B. DeAngelo, R.E. Richmond, J H Carter |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Proto-Oncogene Proteins c-jun Aldehyde dehydrogenase Dichloroacetic acid Oncogene Protein p21(ras) medicine.disease_cause Immunoenzyme Techniques chemistry.chemical_compound medicine Biomarkers Tumor Animals Carcinogen Glutathione Transferase biology Dichloroacetic Acid Liver Neoplasms Hyperplasia Aldehyde Dehydrogenase medicine.disease Rats Inbred F344 Rats Glutathione S-transferase Oncology chemistry biology.protein Immunohistochemistry alpha-Fetoproteins Carcinogenesis Alpha-fetoprotein Proto-Oncogene Proteins c-fos Cell Division |
| Zdroj: | Cancer letters. 92(1) |
| ISSN: | 0304-3835 |
| Popis: | We examined the incidence of proliferative lesions, hyperplastic nodules and altered hepatic foci, in male F344 rat liver, to determine their preneoplastic potential during dichloroacetic acid (DCA)-induced hepatocarcinogenesis. Immunohistochemical and image analysis methods were used to detect the expression of 6 histochemical markers of neoplastic cells; p21 ras, p39 c-jun, p55 c-fos, aldehyde dehydrogenase (ALDH), glutathione s-transferase (GST-p), and alpha fetoprotein (AFP) during DCA-induced hepatocarcinogenesis. Our results were consistent with our previous data and suggested that the hyperplastic nodules, rather than altered hepatic foci, is a putative preneoplastic lesion during DCA-induced hepatocarcinogenesis in the male F344 rat. |
| Databáze: | OpenAIRE |
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