Atrial fibrillation, anticoagulation management and risk of stroke in the Cardiomyopathy/Myocarditis registry of the EURObservational Research Programme of the European Society of Cardiology

Autor: Juan R. Gimeno, Michal Tendera, Akinsanya Olusegun-Joseph, Simone Sala, Philippe Charron, Cécile Laroche, María Luisa Peña-Peña, Luigi Tavazzi, Yigal M. Pinto, Attila Frigy, Alida L.P. Caforio, Aldo P. Maggioni, Angelos G. Rigopoulos, Juan Pablo Kaski, Elisabetta Zachara, Olga Blagova, Fabrizio Drago, Elena V. Reznik, Perry M. Elliott, Katarzyna Mizia-Stec
Přispěvatelé: Silesian Medical University, Katowice, Poland, Universita degli Studi di Padova, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University College of London [London] (UCL), Great Ormond Street Hospital for Children [London] (GOSH), Martin-Luther-University Halle-Wittenberg, Hospital Universitario Virgen del Rocío [Sevilla], University of Lagos, Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), Ospedale San Raffaele, IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Sechenov First Moscow State Medical University, Cardiology, ACS - Heart failure & arrhythmias
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: ESC Heart Failure, Vol 7, Iss 6, Pp 3601-3609 (2020)
ESC Heart Failure
ESC Heart Failure, Wiley, 2020, ⟨10.1002/ehf2.12854⟩
ESC heart failure, 7(6), 3601-3609. The Heart Failure Association of the European Society of Cardiology
ISSN: 2055-5822
Popis: International audience; Aims: Cardiomyopathies are a heterogeneous group of disorders that increase the risk for atrial fibrillation (AF). The aim of the study is to assess the prevalence of AF, anticoagulation management, and risk of stroke/transient ischaemic attack (TIA) in patients with cardiomyopathy.Methods and results: Three thousand two hundred eight consecutive adult patients with cardiomyopathy (34.9% female; median age: 55.0 years) were prospectively enrolled as part of the EURObservational Research Programme Cardiomyopathy/Myocarditis Registry. At baseline, 903 (28.2%) patients had AF (29.4% dilated, 27.5% hypertrophic, 51.5% restrictive, and 14.7% arrhythmogenic right ventricular cardiomyopathy, P < 0.001). AF was associated with more advanced New York Heart Association class (P < 0.001), increased prevalence of cardiovascular risk factors and co-morbidities, and a history of stroke/TIA (P < 0.001). Oral anticoagulation was administered in 71.7% of patients with AF (vitamin K antagonist: 51.6%; direct oral anticoagulant: 20.1%). At 1 year follow-up, the incidence of cardiovascular endpoints was as follows: stroke/TIA 1.85% (AF vs. non-AF: 3.17% vs. 1.19%, P < 0.001), death from any cause 3.43% (AF vs. non-AF: 5.39% vs. 2.50%, P < 0.001), and death from heart failure 1.67% (AF vs. non-AF: 2.44% vs. 1.31%, P = 0.033). The independent predictors for stroke/TIA were as follows: AF [odds ratio (OR) 2.812, P = 0.005], history of stroke (OR 7.311, P = 0.010), and anaemia (OR 3.119, P = 0.006).Conclusions: The study reveals a high prevalence and diverse distribution of AF in patients with cardiomyopathies, inadequate anticoagulation regimen, and high risk of stroke/TIA in this population.
Databáze: OpenAIRE
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