Chromosome mapping of the human genes encoding the MAP kinase kinase MEK1 (MAP2K1) to 15q21 and MEK2 (MAP2K2) to 7q32
| Autor: | K. Gopalbhai, Sylvain Meloche, J. Pellerin, Stephen W. Scherer, Barbara G. Beatty |
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| Rok vydání: | 2000 |
| Předmět: |
MAP Kinase Kinase 2
Molecular Sequence Data MAPK7 MAP Kinase Kinase 1 Hybrid Cells Protein Serine-Threonine Kinases Mitogen-activated protein kinase kinase Biology environment and public health MAP2K7 Genetics Humans c-Raf Cloning Molecular Chromosomes Artificial Yeast Molecular Biology In Situ Hybridization Fluorescence Genetics (clinical) MAPK14 Mitogen-Activated Protein Kinase Kinases Chromosomes Human Pair 15 MAP kinase kinase kinase MAPKAPK2 Sequence Analysis DNA Protein-Tyrosine Kinases Physical Chromosome Mapping Molecular biology Cell biology Isoenzymes Blotting Southern Cyclin-dependent kinase 9 Chromosomes Human Pair 7 Pseudogenes Chromosomes Human Pair 8 |
| Zdroj: | Cytogenetic and Genome Research. 88:249-252 |
| ISSN: | 1424-859X 1424-8581 |
| DOI: | 10.1159/000015530 |
| Popis: | Activation of the ERK mitogen-activated protein (MAP) kinase pathway has been implicated in the regulation of cell growth, differentiation and senescence. In this pathway, the MAP kinases ERK1/ERK2 are phosphorylated and activated by the dual-specificity kinases MEK1 and MEK2, which in turn are activated by serine phosphorylation by a number of MAP kinase kinase kinases. We report here the chromosomal localization of the human genes encoding the MAP kinase kinase isoforms MEK1 and MEK2. Using a combination of fluorescence in situ hybridization, somatic cell hybrid analysis, DNA sequencing and yeast artificial chromosome (YAC) clone analysis, we have mapped the MEK1 gene (MAP2K1) to chromosome 15q21. We also present evidence for the presence of a MEK1 pseudogene on chromosome 8p21. The MEK2 gene (MAP2K2) was mapped to chromosome 7q32 by fluorescence in situ hybridization and YAC clone analysis. |
| Databáze: | OpenAIRE |
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