Effects of Eprosartan on Diastolic Function and Neurohormones in Patients with Hypertension and Diastolic Dysfunction

Autor: Dirk J. van Veldhuisen, Adriaan A. Voors, Thijs W. M. Plokker, Richard G. Vijn, Jasper W. L. Hartog, W. Jaarsma, Ruud M.A. van de Wal, Yoran M. Hummel
Přispěvatelé: Cardiovascular Centre (CVC)
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Male
Angiotensin receptor
ATENOLOL SILVHIA
ANTIHYPERTENSIVE TREATMENT
urologic and male genital diseases
Left ventricular hypertrophy
Ventricular Function
Left
Neurohormones
Tissue doppler
Diastole
Natriuretic Peptide
Brain
Ventricular Dysfunction
Ventricular Function
Pharmacology (medical)
Natriuretic peptides
Aldosterone
Neurotransmitter Agents
Imidazoles
Heart
General Medicine
Middle Aged
female genital diseases and pregnancy complications
CHRONIC HEART-FAILURE
EUROPEAN-SOCIETY
PROGNOSTIC VALUE
Treatment Outcome
Acrylates
Echocardiography
Hypertension
Cardiology
Blood pressure
Female
Cardiology and Cardiovascular Medicine
GLYCATION END-PRODUCTS
hormones
hormone substitutes
and hormone antagonists
medicine.drug
medicine.medical_specialty
Diastolic function
MYOCARDIAL FIBROSIS
Heart failure
Thiophenes
Peptidyl-Dipeptidase A
Article
EJECTION FRACTION
LEFT-VENTRICULAR HYPERTROPHY
Internal medicine
medicine
Humans
cardiovascular diseases
Antihypertensive Agents
Aged
Pharmacology
business.industry
Eprosartan
Stroke Volume
medicine.disease
Peptide Fragments
RANDOMIZED-TRIAL
Regimen
business
Angiotensin II Type 1 Receptor Blockers
Zdroj: Cardiovascular Drugs and Therapy
Cardiovascular Drugs and Therapy, 24(1), 33-40. SPRINGER
ISSN: 0920-3206
DOI: 10.1007/s10557-010-6221-4
Popis: To compare the effects of an angiotensin receptor blocker(ARB)-based regimen versus a non-ARB based regimen on diastolic function and neurohormones in patients with hypertension and diastolic dysfunction.97 patients with a systolic blood pressure (SBP) a parts per thousand yen140 mmHg, a left ventricular ejection fraction > 0.50, and echocardiographic evidence of diastolic dysfunction were randomly assignment to open-label treatment with eprosartan (with other anti-hypertensives; n = 47) or other anti-hypertensives alone (n = 50). Echocardiography, including tissue Doppler imaging (TDI), and neurohormones were done at baseline and after 6 months.Mean age was 65 (+/- 10) years and 64% was female. During 6 months of treatment, SBP decreased from 157 +/- 16 to 145 +/- 18 mmHg in the eprosartan group and from 158 +/- 17 to 141 +/- 18 mmHg in the control group (both p Lowering blood pressure, either with eprosartan or other anti-hypertensives in hypertensive patients with diastolic dysfunction did not change diastolic function after 6 months of treatment, but was associated with a decrease of NT-proBNP.
Databáze: OpenAIRE
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