Retrieval of Consolidated Spatial Memory in the Water Maze Is Correlated with Expression of pCREB and Egr1 in the Hippocampus of Aged Mice
| Autor: | XiaoGuang Zhang, WanXia Xiong, ShengJin Ge, Guo-Xia Zhou |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
endocrine system Early growth response protein 1 Cognitive Neuroscience EGR1 Water maze Hippocampal formation lcsh:Geriatrics Aged mouse Hippocampus lcsh:RC346-429 Internal medicine medicine Hippocampus (mythology) Original Research Article lcsh:Neurology. Diseases of the nervous system Probe trial Spatial probe test Cyclic AMP response element-binding protein Psychiatry and Mental health lcsh:RC952-954.6 Endocrinology nervous system Psychology Neuroscience |
| Zdroj: | Dementia and Geriatric Cognitive Disorders EXTRA Dementia and Geriatric Cognitive Disorders Extra, Vol 3, Iss 1, Pp 39-47 (2013) |
| ISSN: | 1664-5464 |
| Popis: | Objective: To study the relationship of the expression of phosphorylated cyclic AMP response element-binding protein (pCREB) and early growth response protein 1 (Egr1) in the hippocampus of aged mice with retrieval of consolidated spatial memory in a water maze. Methods: Twenty-four aged mice were allocated into no training or probe test (naïve), no training but exposed to the same probe test (NTPRT), received training and probe test (PRT), and received training but no probe test (NPRT) groups. Twelve mice were trained in a water maze over 14 days. After the final probe trial on day 15, all mice were anesthetized and the brains were removed. pCREB immunoreactivity (pCREB-ir) and Egr1 immunoreactivity (Egr1-ir) in the hippocampal CA1 and CA3 areas were examined. Results: pCREB-ir and Egr1-ir in the CA1 and CA3 areas of the NPRT and PRT groups were significantly higher than those of the naïve and NTPRT groups, and those in the PRT group were significantly higher than in the NPRT group. In all groups, pCREB-ir was significantly higher in the CA3 area compared to the CA1 area, while Egr1-ir was significantly higher in the CA1 area compared to the CA3 area. Conclusion: Retrieval, as well as formation, of consolidated spatial memory in the water maze is correlated with expression of pCREB and Egr1 in the hippocampus of aged mice. |
| Databáze: | OpenAIRE |
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