Polarimetric imaging of amyloid
| Autor: | Werner Kaminksy, Kacey Claborn, Lee-Way Jin, Steven Powell, Charles W. Branham, Izumi Maezawa, Bart Kahr |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Circular dichroism
Amyloid Polarimetry General Physics and Astronomy Plaque Amyloid In Vitro Techniques Linear dichroism chemistry.chemical_compound Nuclear magnetic resonance Structural Biology Microscopy medicine Humans General Materials Science Brain Chemistry Birefringence Staining and Labeling Amyloidosis Circular Dichroism Congo Red Cell Biology medicine.disease Congo red chemistry Microscopy Polarization |
| Zdroj: | Micron (Oxford, England : 1993). 37(4) |
| ISSN: | 0968-4328 |
| Popis: | New developments in optical microscopy are discussed with relevance to the imaging of amyloid plaques that are pathognomonic of a variety of degenerative disorders. We present the results of linear birefringence, linear dichroism, and circular dichroism imaging of Congo red stained plaques ex vivo and in vitro. A new technique for measuring rapid changes in linear anisotropies is introduced. The application of polarimetric imaging as demonstrated here can be extended to broader pathological practice since polarimetric measurements are sensitive to transformations in tissues that are specific disease signatures. |
| Databáze: | OpenAIRE |
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