The relationship between tumour T-lymphocyte infiltration, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer
| Autor: | K. Canna, P A McArdle, Colin S. McArdle, A.-M. McNicol, G. W. Smith, Ruth F. McKee, Donald C. McMillan |
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| Rok vydání: | 2005 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Cancer Research Pathology medicine.medical_specialty Colorectal cancer T-Lymphocytes colorectal cancer CD8-Positive T-Lymphocytes Gastroenterology survival C-reactive protein Predictive Value of Tests Internal medicine Clinical Studies medicine Humans Neoplasm Invasiveness Survival analysis Aged Univariate analysis CD4+ and CD8+ T-lymphocytes biology business.industry Acute-phase protein Middle Aged medicine.disease Immunohistochemistry Survival Analysis Systemic Inflammatory Response Syndrome Oncology Lymphatic Metastasis biology.protein Female business Colorectal Neoplasms Infiltration (medical) CD8 |
| Zdroj: | British Journal of Cancer |
| ISSN: | 0007-0920 |
| Popis: | There is increasing evidence that both local and systemic inflammatory responses play an important role in the progression of a variety of common solid tumours. The aim of the present study was to examine the relationship between tumour T-lymphocyte subset infiltration, the systemic inflammatory response and cancer-specific survival in patients with colorectal cancer. In all, 147 patients undergoing potentially curative resection for colorectal cancer were studied. Circulating concentrations of C-reactive protein were measured prior to surgery. CD4+ and CD8+ T-lymphocyte infiltration of the tumour was assessed using immunohistochemistry and a point counting technique. When patients were grouped according to the percentage tumour volume of CD4+ T-lymphocytes, there was no difference in terms of age, sex, tumour site, stage and tumour characteristics. However, there was an inverse relationship between percentage tumour CD4+ T-lymphocytes and C-reactive protein (P |
| Databáze: | OpenAIRE |
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