Differential Distribution of Tryptophan-Metabolites in Fetal and Maternal Circulations During Normotensive and Preeclamptic Pregnancies
| Autor: | Hui-Hui Li, Kai Wang, Ying-Ying Wei, Derek S. Boeldt, Chi Zhou, Wei Lei, Ying-Jie Zhao, Jing Zheng |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pregnancy Fetus business.industry Tryptophan Obstetrics and Gynecology Biological activity medicine.disease Umbilical vein Article Preeclampsia Endocrinology Pre-Eclampsia Internal medicine Human Umbilical Vein Endothelial Cells Medicine Humans Female Serotonin Viability assay business Kynurenine |
| Zdroj: | Reprod Sci |
| ISSN: | 1933-7205 |
| Popis: | Preeclampsia (PE) is a hypertensive pregnancy, which is a leading cause of maternal and fetal morbidity and mortality during pregnancy. L-Tryptophan (Trp) is an essential amino acid, which can be metabolized into various biologically active metabolites. However, the levels of many circulating Trp-metabolites in human normotensive pregnancies (NT) and PE are undetermined. This study quantified the levels of Trp-metabolites in maternal and umbilical vein sera from women with NT and PE. Paired maternal and umbilical blood samples were collected from singleton pregnant patients. Twenty-five Trp-metabolites were measured in serum samples using liquid chromatography with tandem mass spectrometry. The effects of L-kynurenine (Kyn) and indole-3-lactic acid (ILA), on function of human umbilical vein endothelial cells (HUVECs), were also determined. Twenty Trp-metabolites were detected. The levels of 9 Trp-metabolites including Kyn and ILA were higher (P |
| Databáze: | OpenAIRE |
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