New theca-cell marker insulin-like factor 3 is associated with premature ovarian insufficiency
Autor: | Shidou Zhao, Xue Jiao, Jingmei Hu, Chendi Zhu, Zhuqing Li, Wei Luo, Yingying Qin, Xiruo Zhang |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Adult endocrine system medicine.medical_specialty Primary Ovarian Insufficiency Premature ovarian insufficiency Cohort Studies 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine Follicular phase medicine Humans Insulin Ovarian reserve Testosterone Retrospective Studies 030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology Proteins Retrospective cohort study Antral follicle Follicular fluid 030104 developmental biology Endocrinology Reproductive Medicine Theca Cells Female business Luteinizing hormone Biomarkers |
Zdroj: | Fertility and sterility. 115(2) |
ISSN: | 1556-5653 |
Popis: | To characterize circulating insulin-like factor 3 (INSL3) in different stages of ovarian insufficiency and its role in the evaluation of premature ovarian insufficiency (POI).Retrospective cohort study.University-based center for reproductive medicine.A total of 145 women, including 48 patients with POI (25 IU/Lfollicle-stimulating hormone [FSH] ≤40 IU/L), 49 with biochemical POI (bPOI) (10 IU/LFSH ≤25 IU/L) and 48 age-matched control women with normal ovarian reserve (FSH10 IU/L), retrospectively included from the reproductive hospital affiliated with Shandong University between 2017 and 2019.Levels of INSL3 in the serum and follicular fluid assayed with a commercial radioimmunoassay.Level of INSL3 in serum and follicular fluid among control women and patients with bPOI and POI, its association with different ovarian reserve markers, and its predictive value for bPOI and POI.The serum INSL3 level continuously declined with the progress of ovarian insufficiency. It showed strong negative association with FSH (-0.655) and luteinizing hormone (-0.433), but positively correlated with antimüllerian hormone (0.617), inhibin B (0.400), antral follicle count (0.630), and testosterone (0.180). Additionally, the circulating INSL3 served as a good predictor for bPOI and POI. No statistically significant difference of INSL3 levels in follicular fluid was observed between bPOI patients and control women.For the first time our study has revealed an INSL3 deficiency in women with POI, indicating that circulating INSL3 could serve as a promising theca-cell specific marker for POI. Future research on the role of INSL3 in modulating follicular development, steroidogenesis, and POI pathogenesis is warranted. |
Databáze: | OpenAIRE |
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