Postmortem quantitative 1.5-T MRI for the differentiation and characterization of serous fluids, blood, CSF, and putrefied CSF
| Autor: | Christian Jackowski, Anders Persson, Frederick Schuster, Nicole Schwendener, Wolf-Dieter Zech, Fabiano Riva, Marcel Warntjes |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Pathology medicine.medical_specialty Short axis 610 Medicine & health Models Biological Postmortem Changes Pathology and Forensic Medicine Body Temperature Cerebrospinal fluid Image Processing Computer-Assisted Medicine Humans Statistical analysis Putrefaction Forensic Pathology Cerebrospinal Fluid medicine.diagnostic_test business.industry Myocardium Brain Magnetic resonance imaging Thrombosis Middle Aged Magnetic Resonance Imaging Well differentiated Body Fluids Serous fluid Blood Female business Nuclear medicine Pericardium |
| Zdroj: | Zech, Wolf-Dieter; Schwendener, Nicole; Persson, Anders; Warntjes, Marcel J; Riva, Fabiano; Schuster, Frederick; Jackowski, Christian (2015). Postmortem quantitative 1.5-T MRI for the differentiation and characterization of serous fluids, blood, CSF, and putrefied CSF. International journal of legal medicine, 129(5), pp. 1127-1136. Springer 10.1007/s00414-015-1218-y |
| DOI: | 10.1007/s00414-015-1218-y |
| Popis: | The purpose of the present study was to investigate whether serous fluids, blood, cerebrospinal fluid (CSF), and putrefied CSF can be characterized and differentiated in synthetically calculated magnetic resonance (MR) images based on their quantitative T 1, T 2, and proton density (PD) values. Images from 55 postmortem short axis cardiac and 31 axial brain 1.5-T MR examinations were quantified using a quantification sequence. Serous fluids, fluid blood, sedimented blood, blood clots, CSF, and putrefied CSF were analyzed for their mean T 1, T 2, and PD values. Body core temperature was measured during the MRI scans. The fluid-specific quantitative values were related to the body core temperature. Equations to correct for temperature differences were generated. In a 3D plot as well as in statistical analysis, the quantitative T 1, T 2 and PD values of serous fluids, fluid blood, sedimented blood, blood clots, CSF, and putrefied CSF could be well differentiated from each other. The quantitative T 1 and T 2 values were temperature-dependent. Correction of quantitative values to a temperature of 37 °C resulted in significantly better discrimination between all investigated fluid mediums. We conclude that postmortem 1.5-T MR quantification is feasible to discriminate between blood, serous fluids, CSF, and putrefied CSF. This finding provides a basis for the computer-aided diagnosis and detection of fluids and hemorrhages. |
| Databáze: | OpenAIRE |
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