7-Day Nonbismuth-Containing Concomitant Therapy Achieves a High Eradication Rate for Helicobacter pylori in Taiwan

Autor: Nan-Jing Peng, Hoi-Hung Chan, Ping-I Hsu, Wen-Chi Chen, Hsien-Chung Yu, Hui-Hwa Cheng, Wei-Lun Tsai, Sung-Shuo Kao, Feng-Woei Tsay, Kwok-Hung Lai, Chiun-Ku Lin, Tzung-Jiun Tsai, Huay-Min Wang, Kung-Hung Lin
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Gastroenterology Research and Practice
Gastroenterology Research and Practice, Vol 2012 (2012)
ISSN: 1687-630X
1687-6121
Popis: Background.Ten-day concomitant therapy achieves a high eradication rate in Taiwan. Whether shortening the duration of concomitant therapy can still keep a high eradication rate remains unclear.Aim.To assess the eradication rate of 7-day pantoprazole-containing concomitant therapy in Taiwan and to investigate factors influencing the eradication outcome.Methods.From March 2008 to March 2012, 319H. pylori-infected patients receiving a 7-day pantoprazole-containing concomitant regimen (pantoprazole 40 mg, amoxicillin 1 g, clarithromycin 500 mg, and metronidazole 500 mg twice daily for 7 days) were included. Patients were asked to return at the second week to assess drug compliance and adverse effects. Repeated endoscopy or urea breath test was performed at 8 weeks after the end of eradication therapy.Results.The eradication rates according to intention-to-treat and per-protocol analyses were 93.7% (299/319) and 96.4% (297/308), respectively. Adverse events occurred in 13.2% (42/319) of the patients. The compliance rate was 98.4% (314/319). Multivariate analysis disclosed that poor compliance was the only independent factor influencing the efficacy of anti-H. pyloritherapy with an odds ratio of 0.073 (95% confidence interval, 0.011–0.483).Conclusion.7-day concomitant therapy achieved a very high eradication rate forH. pyloriinfection in Taiwan. Drug compliance was the only clinical factor influencing treatment efficacy.
Databáze: OpenAIRE
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