Segmentally enclosed thrombolysis in percutaneous transluminal angioplasty for femoropopliteal occlusions: a report from a pilot study
| Autor: | K.H. Tønnesen, Bo Jørgensen, Jørn Dalsgaard Nielsen, Jens Bülow, Jørgensen M, Per Holstein, E. Andersen |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Percutaneous Time Factors medicine.medical_treatment Pilot Projects Femoral artery Transluminal Angioplasty Recurrence medicine.artery medicine Coagulopathy Humans Radiology Nuclear Medicine and imaging Popliteal Artery Thrombolytic Therapy Vascular Patency Aged Chemotherapy business.industry Heparin Thrombosis Thrombolysis medicine.disease Surgery Femoral Artery Catheter Tissue Plasminogen Activator Female Cardiology and Cardiovascular Medicine business Angioplasty Balloon medicine.drug |
| Zdroj: | Cardiovascular and interventional radiology. 14(5) |
| ISSN: | 0174-1551 |
| Popis: | Segmentally enclosed thrombolysis (SET) was performed immediately following 34 percutaneous transluminal angioplasties (PTAs) for femoropopliteal occlusions. The dilated segment was sealed off with a double balloon catheter, and recombinant tissue plasminogen activator (rt-PA) 1 mg/ml and heparin 200 IU/ml were injected between the balloons. The catheter was removed after 30 min and heparin treatment was continued for 24 h. Alpha-2-antiplasmin was initially reduced by 13% and normalized 2 h after SET, indicating that only small amounts of free plasmin were liberated during thrombolysis. No clinically relevant changes in plasma fibrinogen occurred. Two puncture site hemorrhages did not coincide with the coagulopathy induced by SET. One-year patency was 80%. Early rethrombosis occurred in 9% versus 41% in our previous series on standard PTA for femoropopliteal occlusions (p less than 0.001). Therefore, SET is considered beneficial in reducing the incidence of early rethrombosis. |
| Databáze: | OpenAIRE |
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