Greater Preexisting Interferon Responses to Mycobacterial Antigens and Lower Bacillary Load During HIV-Associated Tuberculosis
| Autor: | Mecky Matee, Robert D. Arbeit, C. Robert Horsburgh, Kisali Pallangyo, Tom Czechura, Todd A. MacKenzie, C. Fordham von Reyn, Scott Crabtree, Timothy Lahey, Muhammad Bakari |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Tuberculosis HIV Infections Tanzania Mycobacterium tuberculosis Interferon-gamma Young Adult Major Articles and Brief Reports Antigen Interferon medicine Humans Immunology and Allergy Interferon gamma Prospective cohort study Antigens Bacterial biology business.industry Sputum Middle Aged Viral Load medicine.disease biology.organism_classification Virology Bacterial Load Infectious Diseases Immunization Immunology BCG Vaccine Female Tuberculosis vaccines business Interferon-gamma Release Tests medicine.drug |
| Zdroj: | Journal of Infectious Diseases. 208:1629-1633 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Heritable interferon (IFN) γ signaling deficiencies are associated with heightened susceptibility to tuberculosis [1] and deficient IFN-γ responses probably contribute to the high vulnerability to tuberculosis of persons with human immunodeficiency virus (HIV) infection [2]. Among HIV-infected and BCG-immunized adults, we have shown that detectable IFN-γ responses to single and multiple mycobacterial antigens are associated with protection from HIV-associated tuberculosis [3, 4]. To our knowledge, however, there have been no prospective studies evaluating whether IFN-γ responses reduce the tuberculosis bacillary load when active tuberculosis occurs. To address this question, we correlated baseline IFN-γ responses to mycobacterial antigens with the bacillary burden of tuberculosis disease among HIV-infected adults who subsequently developed culture-confirmed tuberculosis in the DarDar phase III tuberculosis vaccine trial in Tanzania. |
| Databáze: | OpenAIRE |
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