SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases
| Autor: | Stephan Mertens, Michel Goedert, Molly Craxton |
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| Rok vydání: | 1996 |
| Předmět: |
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Complementary Molecular Sequence Data Biophysics Saccharomyces cerevisiae Mitogen-activated protein kinase kinase Stress-activated protein kinase Polymerase Chain Reaction Biochemistry SH3 domain MAP2K7 Mice Mitogen-Activated Protein Kinase 12 Structural Biology Genetics Animals ASK1 Amino Acid Sequence c-Raf Cloning Molecular Muscle Skeletal Protein kinase A Molecular Biology Conserved Sequence Protein kinase C DNA Primers Gene Library Base Sequence Sequence Homology Amino Acid Chemistry Brain HOG1 Cell Biology Mitogen-activated protein kinase Autophagy-related protein 13 Rats Cell biology Enzyme Activation Isoenzymes Organ Specificity Calcium-Calmodulin-Dependent Protein Kinases Stress-activated protein kinase-3 Mitogen-Activated Protein Kinases Protein Kinases |
| Zdroj: | FEBS Letters. 383:273-276 |
| ISSN: | 0014-5793 |
| Popis: | Stress-activated protein kinases are MAP kinase homologues that are activated by cellular stresses, bacterial endotoxin and inflammatory cytokines. They are activated by a dual threonine/tyrosine phosphorylation within a TPY sequence in the case of stress-activated protein kinase-1 and its isoforms (also called JNKs) or a TGY sequence in the case of stress-activated protein kinase-2 and its isoforms (also called p38, p40, RK, CSBPs, XMpk2 and Mxi2). Here we report the cloning and sequencing of a new protein kinase from rat with a TGY sequence in the activation domain. This stress-activated protein kinase-3 is 60% identical to mouse stress-activated protein kinase-2 and 45% identical to HOG1 from Saccharomyces cerevisiae. Transcripts encoding stress-activated protein kinase-3 are widely expressed, with high levels in skeletal muscle. |
| Databáze: | OpenAIRE |
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