The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets
| Autor: | Julián Alberto Bélgamo, María F. Rey Burusco, Marina Ibáñez Shimabukuro, Brian O. Smith, Jorge Luis Pórfido, Betina Córsico, Gisela Raquel Franchini, Malcolm W. Kennedy |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Models
Molecular Highly pathogenic Clinical Biochemistry Helminthiasis Parasitism Biology Fatty Acid-Binding Proteins LIPID BINDING PROTEINS Host-Parasite Interactions PARASITIC HELMINTHS Ciencias Biológicas Immune system Helminths Lipid binding Animals Humans Secretion Parasitic helminth Host (biology) Cell Biology Bioquímica y Biología Molecular NEMATODES Cell biology FATTY ACIDS CIENCIAS NATURALES Y EXACTAS |
| Popis: | In this review paper we aim at presenting the current knowledge on structural aspects of soluble lipid binding proteins (LBPs) found in parasitic helminths and to discuss their potential role as novel drug targets. Helminth parasites produce and secrete a great variety of LBPs that may participate in the acquisition of nutrients from their host, such as fatty acids and cholesterol. It is also postulated that LBPs might interfere in the regulation of the host׳s immune response by sequestering lipidic intermediates or delivering bioactive lipids. A detailed comprehension of the structure of these proteins, as well as their interactions with ligands and membranes, is important to understand host–parasite relationships that they may mediate. This information could also contribute to determining the role that these proteins may play in the biology of parasitic helminths and how they modulate the immune systems of their hosts, and also towards the development of new therapeutics and prevention of the diseases caused by these highly pathogenic parasites. Fil: Franchini, Gisela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina Fil: Pórfido, Jorge Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina Fil: Ibáñez, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina Fil: Rey, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina Fil: Bélgamo, Julián Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina Fil: Smith, Brian O.. University of Glasgow; Reino Unido Fil: Kennedy, Malcolm W.. University of Glasgow; Reino Unido Fil: Córsico, Betina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina |
| Databáze: | OpenAIRE |
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