High-dose methylprednisolone is an alternative treatment for adults with autoimmune thrombocytopenic purpura refractory to intravenous immunoglobulins and oral corticosteroids
| Autor: | Jean-Marc Zini, Philippe Bierling, Bertrand Godeau, Annette Schaeffer |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class medicine.medical_treatment Drug Resistance Administration Oral Methylprednisolone Gastroenterology Refractory Adrenal Cortex Hormones Prednisone Internal medicine Immunopathology medicine Humans Platelet Infusions Intravenous Aged Aged 80 and over Autoimmune disease Purpura Thrombocytopenic Idiopathic Chemotherapy business.industry Immunoglobulins Intravenous Hematology Middle Aged medicine.disease Surgery Corticosteroid Female business medicine.drug |
| Zdroj: | American Journal of Hematology. 48:282-284 |
| ISSN: | 1096-8652 0361-8609 |
| DOI: | 10.1002/ajh.2830480416 |
| Popis: | Eight patients with severe chronic autoimmune thrombocytopenic purpura (AITP) refractory to high-dose intravenous immunoglobulin (IVIgG) and/or oral prednisone were treated with one to three infusions of high-dose methylprednisolone (HDMP) (15 mg/kg/day). The mean platelet count before treatment was 12 +/- 10 x 10(9)/L. HDMP therapy led to a safe platelet count (> 50 x 10(9)/L) after 2-5 days in five patients, and a minimal platelet increase (34 x 10(9)/L) able to stop bleeding in a sixth patient. The effect of HDMP was, however, transient in four of five responders. No side effects were observed, even in the four patients older than 70 years. HDMP thus appears to be a good alternative in emergency situations or prior to surgery for patients with AITP refractory to conventional therapy. |
| Databáze: | OpenAIRE |
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