Risk factors for trisomy 21: Maternal cigarette smoking and oral contraceptive use in a spopulation-based case-control study
| Autor: | Stephanie L. Sherman, Quanhe Yang, D Pettay, T J Hassold, S B Freeman, L Taft, J D Erickson, K Allran, Muin J. Khoury |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Genetic Markers medicine.medical_specialty Epidemiologic Factors Polymerase Chain Reaction Interviews as Topic Pregnancy Risk Factors Surveys and Questionnaires Epidemiology Odds Ratio medicine Humans Drug Interactions Genetics (clinical) Gynecology business.industry Obstetrics Smoking Infant Newborn Case-control study Odds ratio medicine.disease Blotting Southern Nondisjunction Case-Control Studies Structured interview Female Down Syndrome Trisomy business Contraceptives Oral |
| Zdroj: | Genetics in Medicine. 1:80-88 |
| ISSN: | 1098-3600 |
| DOI: | 10.1097/00125817-199903000-00004 |
| Popis: | Purpose: We examined maternal smoking and oral contraceptive use as possible risk factors in the genesis of cases of trisomy 21 of maternal origin. This is the first epidemiological study to categorize cases of trisomy 21 by parent of origin and timing of the meiotic error before assessing possible risk factors. Methods: We used chromosome 21-specific DNA markers to assign origin to each case. Structured interviews were employed to deter-mine maternal smoking and oral contraceptive use around conception. Results: The odds ratio (OR) for maternal smoking was significantly increased among younger mothers (OR = 2.98; 95% CI = 1.01–8.87), but only in a particular subset of meiotically-derived cases. The combined use of cigarettes and oral contraceptives increased the risk further (OR = 7.62; 95% CI = 1.63–35.6); however, oral contraceptive use alone was not a significant risk factor. Conclusion: Our results indicate that categorizing cases of trisomy 21 by parent and timing of the meiotic error allows more precision in identifying risk factors and may shed light on mechanisms of meiotic nondisjunction. |
| Databáze: | OpenAIRE |
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