Infection of rhesus monkeys and chimpanzees with Epstein-Barr virus
| Autor: | Paul H. Levine, David A. Stevens, Patricia Fabrizio, S. A. Leiseca, A. P. Andrese, David J. Granlund, J. F. Hewetson, K. A. Traul |
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| Rok vydání: | 1980 |
| Předmět: |
medicine.medical_specialty
Herpesvirus 4 Human Time Factors Pan troglodytes medicine.medical_treatment Antibodies Heterophile medicine.disease_cause Antibodies Viral Virus Serology Medical microbiology Neutralization Tests Virology medicine Animals Immunosuppression Therapy biology Immunosuppression General Medicine medicine.disease Epstein–Barr virus Macaca mulatta Lymphoma Macaca fascicularis Infectious disease (medical specialty) Immunology biology.protein Macaca Antibody |
| Zdroj: | Archives of virology. 66(4) |
| ISSN: | 0304-8608 |
| Popis: | Seventy-two nonhuman primates were entered into a long-term study to evaluate the pathogenicity of Epstein-Barr virus (EBV). Infectious virus was inoculated into 42 rhesus monkeys, 4 chimpanzees and 1 cynomolgus monkey. Immunostimulation or immunosuppression was attempted in 34 of these animals to enhance the oncogenic potential of the virus. Eleven inoculated animals were followed for more than 3 years and two were observed for 8 years. No tumors were observed in any of the animals; however, serological evaluation of the 47 inoculated primates and 25 matched controls indicated that at least 14 rhesus monkeys and the cynomolgus monkey were successfully infected with EBV. The potential use of rhesus monkeys as a model for EBV-induced disease in humans is discussed. |
| Databáze: | OpenAIRE |
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