Regression of Established Cardiac Fibrosis in Hypertensive Heart Disease
| Autor: | Yao Sun, Ivan C. Gerling, Ramareddy V. Guntaka, Karl T. Weber |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty animal structures Cardiac fibrosis Population Blood Pressure 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Fibrosis Internal medicine Internal Medicine Animals Humans Medicine Myofibroblasts education Antihypertensive Agents Heart Failure education.field_of_study Ejection fraction Ventricular Remodeling business.industry Myocardium Remission Induction medicine.disease Regression Hypertensive heart disease Treatment Outcome 030104 developmental biology Blood pressure Heart failure Hypertension Cardiology Cardiomyopathies business Signal Transduction |
| Zdroj: | American Journal of Hypertension. 30:1049-1052 |
| ISSN: | 1941-7225 0895-7061 |
| DOI: | 10.1093/ajh/hpx054 |
| Popis: | Established cardiac fibrosis (ECF) with symptomatic heart failure preserved ejection fraction represents an ever-increasing segment of the hypertensive population. The regression of ECF with attendant improvement in myocardial stiffness and symptomatic failure represents an unmet health care need. Is the regression of ECF in hypertensive heart disease feasible and will stiffness and symptomatic failure be improved? What is the cellular/molecular signaling involved in its regression? What incremental knowledge is needed to proceed effectively? These issues are addressed in this Review. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|