Gain-of-Function Mutations in p53 in Cancer Invasiveness and Metastasis
| Autor: | Maciej B. Olszewski, Katarzyna Roszkowska, Zdzislaw Gajewski, Maria Sady, Slawomir Gizinski |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cell physiology
p53 Epithelial-Mesenchymal Transition invasiveness Regulator Mutation Missense review Apoptosis Biology Malignancy Catalysis law.invention Metastasis Inorganic Chemistry lcsh:Chemistry law microRNA medicine Transcriptional regulation Animals Homeostasis Humans cancer metastasis Physical and Theoretical Chemistry Neoplasm Metastasis Molecular Biology lcsh:QH301-705.5 Spectroscopy gain-of-function Organic Chemistry Cancer General Medicine medicine.disease Computer Science Applications Disease Models Animal MicroRNAs Phenotype lcsh:Biology (General) lcsh:QD1-999 Gain of Function Mutation Cancer research Suppressor Tumor Suppressor Protein p53 |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 4, p 1334 (2020) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | Forty years of research has proven beyond any doubt that p53 is a key regulator of many aspects of cellular physiology. It is best known for its tumor suppressor function, but it is also a regulator of processes important for maintenance of homeostasis and stress response. Its activity is generally antiproliferative and when the cell is damaged beyond repair or intensely stressed the p53 protein contributes to apoptosis. Given its key role in preventing cancer it is no wonder that it is the most frequently mutated gene in human cancer. Surprisingly, a subset of missense mutations occurring in p53 (gain-of-function) cause it to lose its suppressor activity and acquire new functionalities that turn the tumor suppressor protein into an oncoprotein. A solid body of evidence exists demonstrating increased malignancy of cancers with mutated p53 in all aspects considered “hallmarks of cancer”. In this review, we summarize current findings concerning the cellular processes altered by gain-of-function mutations in p53 and their influence on cancer invasiveness and metastasis. We also present the variety of molecular mechanisms regulating these processes, including microRNA, direct transcriptional regulation, protein−protein interactions, and more. |
| Databáze: | OpenAIRE |
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