Orally given gastroprotective capsaicin does not modify aspirin-induced platelet aggregation in healthy male volunteers (human phase I examination)
| Autor: | Gy. Mózsik, János Szolcsányi, I. Juricskay, Judit Papp, Zs. Keszthelyi, Krisztián Tóth, Tamas Habon, Barbara Sandor |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Platelet aggregation Adolescent Platelet Aggregation Platelet Function Tests Administration Oral Pharmacology chemistry.chemical_compound Young Adult Physiology (medical) Induced platelet aggregation Medicine Ingestion Humans Platelet Drug Interactions Single-Blind Method Aspirin Hungary business.industry General Medicine Platelet Aggregation Inhibition Middle Aged Anti-Ulcer Agents digestive system diseases Healthy Volunteers surgical procedures operative Epinephrine chemistry Capsaicin lipids (amino acids peptides and proteins) business Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Acta physiologica Hungarica. 101(4) |
| ISSN: | 0231-424X |
| Popis: | Capsaicin is a well-known component of red pepper. Recent studies have shown that capsaicin could prevent gastric ulcer provoked by various NSAID-s like acetylsalicylic acid (ASA). Primary objective of this human clinical phase I trial was to investigate whether two different doses of capsaicin co-administered with ASA could alter the inhibitory effect of ASA on platelet aggregation. 15 healthy male subjects were involved in the study and treated orally with 400 μg capsaicin, 800 μg capsaicin, 500 mg ASA, 400 μg capsaicin+500 mg ASA and 800 μg capsaicin+500 mg ASA. Blood was drawn before and 1, 2, 6 and 24 hours after the drug administration. After that epinephrine induced platelet aggregation was measured by optical aggregometry. Between treatments, volunteers had a 6-day wash-out period. Our results showed that capsaicin had no effect on platelet aggregation, while as expected, ASA monotherapy resulted in a significant and clinically effective platelet aggregation inhibition (p ≤ 0.001). The combined ASA-capsaicin therapies reached equivalent effectiveness in platelet aggregation inhibition as ASA monotherapy. Our investigation proved that capsaicin did not influence the inhibitory effect of ASA on platelet aggregation, thus the capsaicin-ASA treatment would combine the antiplatelet effect of ASA with the possible gastroprotection of capsaicin. |
| Databáze: | OpenAIRE |
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