A projection specific logic to sampling visual inputs in mouse superior colliculus
| Autor: | Chen Li, Quan Do, Karl Farrow, Katja Reinhard, Steven Heynderickx, Emily Burke |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Retinal Ganglion Cells Life Sciences & Biomedicine - Other Topics retina RETINAL GANGLION-CELLS Mouse MOTION NEURONAL CIRCUIT superior colliculus Mice chemistry.chemical_compound 0302 clinical medicine Biology (General) Projection (set theory) 0303 health sciences Behavior Animal General Neuroscience Electroencephalography General Medicine Neuroanatomical Tract-Tracing Techniques medicine.anatomical_structure Retinal ganglion cell Medicine Life Sciences & Biomedicine Research Article Superior Colliculi Cell type CORTEX QH301-705.5 Science Models Neurological pulvinar parabigeminal nucleus Sensory system Biology Retinal ganglion General Biochemistry Genetics and Molecular Biology CLASSIFICATION 03 medical and health sciences medicine Animals Visual Pathways DIRECTION SELECTIVITY FIELD visual circuits 030304 developmental biology Instinct Retina Science & Technology General Immunology and Microbiology Superior colliculus Retinal Electrophysiology 030104 developmental biology chemistry PATTERNS STARBURST AMACRINE CELLS Neuroscience 030217 neurology & neurosurgery RESPONSES |
| Zdroj: | eLife eLife, Vol 8 (2019) |
| Popis: | Using sensory information to trigger different behaviours relies on circuits that pass-through brain regions. However, the rules by which parallel inputs are routed to different downstream targets is poorly understood. The superior colliculus mediates a set of innate behaviours, receiving input from ~30 retinal ganglion cell types and projecting to behaviourally important targets including the pulvinar and parabigeminal nucleus. Combining transsynaptic circuit tracing with in-vivo and ex-vivo electrophysiological recordings we observed a projection specific logic where each collicular output pathway sampled a distinct set of retinal inputs. Neurons projecting to the pulvinar or parabigeminal nucleus uniquely sampled 4 and 7 cell types, respectively. Four others innervated both pathways. The visual response properties of retinal ganglion cells correlated well with those of their disynaptic targets. These findings suggest that projection specific sampling of retinal inputs forms a mechanistic basis for the selective triggering of visually guided behaviours by the superior colliculus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|