Basophil histamine release induced by anti-IgE and concanavalin A Relation to the total plasma IgE content
| Autor: | Bjarne Lühr Hansen, Tine Engberg Damsgaard, Troels Herlin, Peter Oluf Schiøtz, U. Søderberg, Torbjørn Bjerke, Kristian Thestrup-Pedersen, B. Windelborg Nielsen |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
medicine.medical_specialty Immunology Population Dose-Response Relationship Immunologic Enzyme-Linked Immunosorbent Assay Basophil Immunoglobulin E Histamine Release chemistry.chemical_compound Internal medicine Concanavalin A medicine Humans Immunology and Allergy education education.field_of_study Total plasma biology Receptors IgE Immunization Passive Lectin Fetal Blood Basophils Cross-Linking Reagents medicine.anatomical_structure Endocrinology chemistry Cord blood biology.protein Histamine |
| Zdroj: | Allergy. 48:54-61 |
| ISSN: | 1398-9995 0105-4538 |
| Popis: | The plant lectin concanavalin A (Con A) has been shown to induce basophil histamine release by an IgE-receptor-dependent process resembling that of anti-IgE-antibodies. In this study, the concentration-response for basophil histamine release from washed blood cells was analyzed in a population of blood samples from adults with a total plasma IgE content ranging from 18000 kU/l (n= 108), as well as 148 cord blood samples. The concentration-response-curves for anti-IgE in all adult blood samples were similar, despite the large variation in total plasma IgE - only the cord blood samples showed a decreased sensitivity. In contrast, the optimal concentration of Con A was inversely related to plasma IgE, and this relation was most pronounced in the adult blood samples. It is proposed that IgE-receptor-mediated histamine release may be dependent not only on the number of stimulatory, dimeric cross-links formed between IgE-receptors, but also on the molecular structure of the cross-linking agent. |
| Databáze: | OpenAIRE |
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