Efficacy of Dairy Free Diet and 6-Food Elimination Diet as Initial Therapy for Pediatric Eosinophilic Esophagitis: A Retrospective Single-Center Study
| Autor: | Beth Chatfield, Katherine S. Vance, Sue Goodine, Zhu Wang, Kate Samela, Wael N. Sayej, Jonathan Wong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Proton pump inhibitors Proton-pump inhibitor Single Center Gastroenterology 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Internal medicine Elimination diet Concomitant Therapy medicine Eosinophilic esophagitis Hepatology medicine.diagnostic_test business.industry Retrospective cohort study medicine.disease Endoscopy Restriction diet therapy Concomitant Pediatrics Perinatology and Child Health 030211 gastroenterology & hepatology Original Article business |
| Zdroj: | Pediatric Gastroenterology, Hepatology & Nutrition |
| ISSN: | 2234-8840 2234-8646 |
| Popis: | Purpose Management of eosinophilic esophagitis (EoE) varies from center to center. In this study, we evaluated the effectiveness of a dairy-free diet (DFD) and the 6-Food Elimination Diet (SFED) as initial therapies for the treatment of EoE in our practice. Methods This was a retrospective study of children who had been treated for EoE at Connecticut Children's Medical Center, Hartford, CT, USA. Pre- and post-treatment endoscopy findings and histology results of patients treated with DFD or SFED were examined. Results One hundred fifty-two patients (age 9.2±5.2 years, 76.3% male, 69.7% caucasian) met the inclusion criteria for initial treatment with DFD (n=102) or SFED (n=50). Response for DFD was 56.9% and for SFED was 52.0%. Response based on treatment duration (12 weeks) were 81.8%, 50.0%, and 55.1% for DFD, and 68.8%, 50.0%, and 40.0% for SFED. Response based on age (12 years) were 59.3%, 42.9%, and 67.5% for DFD, and 36.4%, 58.8%, and 72.7% for SFED. In patients treated with DFD, concomitant proton pump inhibitor (PPI) administration resulted in improved outcomes (p=0.0177). Bivariate regression analysis showed that PPI with diet is the only predictor of response (p=0.0491), however, there were no significant predictors on multiple regression analysis. Conclusion DFD and SFED are effective first line therapies for EoE. DFD should be tried first before extensive elimination diets. Concomitant therapy with PPI's may be helpful. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|