Prognostic value of preoperative serum immunosuppressive acidic protein in patients with esophageal squamous cell carcinoma
| Autor: | Hiromasa Matsubara, Yoshihiro Nabeya, S Okazumi, Haruyuki Hayashi, Yukimasa Miyazawa, Taito Aoki, T Shihratori, Sohei Kobayashi, Takenori Ochiai, Yoshio Gunji, Makoto Sugaya, Hideaki Shimada |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
musculoskeletal diseases Oncology medicine.medical_specialty Esophageal Neoplasms Preoperative care Immunoenzyme Techniques Internal medicine Preoperative Care Biomarkers Tumor medicine Carcinoma Humans Stage (cooking) Lymph node Aged Proportional Hazards Models biology Proportional hazards model business.industry C-reactive protein Gastroenterology Cancer General Medicine Prognosis medicine.disease Neoplasm Proteins body regions C-Reactive Protein medicine.anatomical_structure Tumor progression Carcinoma Squamous Cell biology.protein Female biological phenomena cell phenomena and immunity business |
| Zdroj: | Diseases of the Esophagus. 16:102-106 |
| ISSN: | 1442-2050 1120-8694 |
| DOI: | 10.1046/j.1442-2050.2003.00306.x |
| Popis: | Immunosuppressive acidic protein (IAP) is a potent biological marker of immunological surveillance in patients with malignant tumors. The aim of this study was to analyze the clinicopathologic significance of IAP in patients with esophageal carcinoma. Preoperative serum IAP concentration was measured by enzyme-linked immunosorbent assay in 115 patients with primary esophageal squamous cell carcinomas. The associations between clinicopathologic factors, C-reactive protein (CRP) values and IAP concentration were determined. Prognostic values were determined by multivariate analysis using Cox's proportional hazards model. The IAP concentration is significantly higher in patients with stage II-IV cancers than in those with stage I cancer. Significant differences in IAP concentration were observed depending upon tumor size, tumor depth, lymph node status and CRP values. A high IAP concentration, more than 500 micro g/mL, was an independent prognostic factor. Thus, a high IAP concentration is associated with tumor progression and poor survival in patients with esophageal squamous cell carcinoma. |
| Databáze: | OpenAIRE |
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