Reproductive, productivity, and mortality outcomes in late-gestation gilts and their litters following simulation of inadvertent exposure to a modified-live vaccine strain of porcine reproductive and respiratory syndrome (PRRS) virus
| Autor: | Deb Amodie, Joel Nerem, Scott Dee, Richard Swalla, Adam Schelkopf, Bobby Cowles |
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| Rok vydání: | 2014 |
| Předmět: |
Litter (animal)
Swine viruses animal diseases Birth weight Porcine Reproductive and Respiratory Syndrome Viremia Biology Antibodies Viral Vaccines Attenuated Random Allocation Animal science Fetus Pregnancy medicine Animals Porcine respiratory and reproductive syndrome virus Attenuated vaccine General Veterinary General Immunology and Microbiology Public Health Environmental and Occupational Health virus diseases Transplacental Viral Vaccines Stillbirth medicine.disease Virus Shedding Vaccination Infectious Diseases Treatment Outcome Immunology Molecular Medicine Gestation Female |
| Zdroj: | Vaccine. 32(36) |
| ISSN: | 1873-2518 |
| Popis: | The study evaluated the safety of a modified live-virus (MLV) porcine reproductive and respiratory syndrome (PRRS) vaccine in susceptible, pregnant gilts. To simulate inadvertent exposure secondary to postvaccination shedding of PRRS-MLV, seronegative gilts (n=51) were exposed by IM vaccination at 90 days of gestation. Vaccinated and nonvaccinated, seronegative control gilts (n=25) were maintained in separate facilities. The PRRS-MLV vaccine was given in a 2mL dose on day 0. On day 7 all vaccinated gilts were PRRSV-PCR-positive for PRRSV and had responded serologically as determined by an ELISA. All control gilts remained PRRSV-PCR- and ELISA-negative throughout the study. Abortions did not occur in gilts from either group. The difference between vaccinated and control gilts in average number of piglets per litter (12.43 and 12.16, respectively), number of live births per litter (11.21 and 11.54), and mean piglet birth weight (3.22 and 3.26 lbs) were not significantly different. Piglets in the control group had significantly greater average daily gain versus piglets from vaccinated gilts (0.52 vs. 0.46 lbs, P |
| Databáze: | OpenAIRE |
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