The added value of chest imaging after neoadjuvant radiotherapy for soft tissue sarcoma of the extremities and trunk wall

Autor: Ibtissam Acem, Bob T.A. Schultze, Alja Schoonbeek, Winan J. van Houdt, Michiel A.J. van de Sande, Jacob J. Visser, Dirk J. Grünhagen, Cornelis Verhoef
Přispěvatelé: Surgery, Radiation Oncology, Radiology & Nuclear Medicine
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: European Journal of Surgical Oncology, 48(7), 1543-1549. W.B. Saunders
European Journal of Surgical Oncology, 48(7), 1543-1549. ELSEVIER SCI LTD
ISSN: 0748-7983
Popis: Introduction: There is no clear evidence regarding the benefit of restaging for distant metastases after neoadjuvant radiotherapy (RTX) in patients with soft tissue sarcoma (STS) of the extremities and trunk wall. This study aimed to determine how often restaging of the chest identified metastatic disease that altered management in these patients.Methods: We performed a single-centre retrospective study from 2010 to 2020. All patients with non-metastatic STS of the extremities and trunk wall who were treated with neoadjuvant RTX and received a staging and restaging chest CT scan or X-ray for distant metastasis were included. The outcome of interest was change in treatment strategy due to restaging after neoadjuvant RTX.Results: Within the 144 patients who were staged and treated with neoadjuvant RTX, a restaging chest CT or X-ray was performed in 134 patients (93%). A change in treatment strategy due to new findings at restaging after RTX was observed in 26 out of 134 patients (19%). In 24 patients the scheduled resection of the primary STS was cancelled at restaging (24/134, 18%), given the findings at restaging. The other two patients did receive the intended local resection, but either with palliative intent, or as a part of a previously unplanned multimodality treatment.Conclusion: In approximately one in five patients restaging results in a change in treatment strategy. This underlines the added value of routine restaging for distant metastases with chest CT or X-ray after neoadjuvant RTX in patients with STS. (c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Databáze: OpenAIRE
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