Association of the c.385C>A (p.Pro129Thr) polymorphism of the fatty acid amide hydrolase gene with anorexia nervosa in the Japanese population

Autor: Yuri Okamoto, Toshihiro Nakahara, Takao Yamanaka, Yuhei Ichimaru, Keisuke Kawai, Masanori Koide, Gen Komaki, Tetsuro Naruo, Mari Hotta, Nobuo Kiriike, Toshio Ishikawa, Naho Tamura, Toshihiko Nagata, Chikara Yamaguchi, Michiko Takei, Chihiro Morita, Tetsuya Ando, Chiemi Nakamoto, Takashi Mera, Kazuyoshi Ookuma
Rok vydání: 2014
Předmět:
Zdroj: Molecular Genetics & Genomic Medicine
ISSN: 2324-9269
Popis: The functional c.385C>A single-nucleotide polymorphism (SNP) in the fatty acid amide hydrolase (FAAH) gene, one of the major degrading enzymes of endocannabinoids, is reportedly associated with anorexia nervosa (AN). We genotyped the c.385C>A SNP (rs324420) in 762 lifetime AN and 605 control participants in Japan. There were significant differences in the genotype and allele frequencies of c.385C>A between the AN and control groups. The minor 385A allele was less frequent in the AN participants than in the controls (allele-wise, odds ratio = 0.799, 95% confidence interval [CI] 0.653–0.976, P = 0.028). When the cases were subdivided into lifetime restricting subtype AN and AN with a history of binge eating or purging, only the restricting AN group exhibited a significant association (allele-wise, odds ratio = 0.717, 95% CI 0.557–0.922, P = 0.0094). Our results suggest that having the minor 385A allele of the FAAH gene may be protective against AN, especially restricting AN. This finding supports the possible role of the endocannabinoid system in susceptibility to AN.
Databáze: OpenAIRE
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