FDG-PET/CT of head and neck squamous cell carcinoma in a rat model

Autor: François Paraf, Karine Aubry, Ziyang Shao, Jean Pierre Bessede, Jacques Monteil, Michel Rigaud
Přispěvatelé: École Polytechnique de Montréal (EPM), Université de Limoges (UNILIM), Equipe de Recherche Médicale Appliquée (ERMA), Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Université de Limoges (UNILIM)-CHU Limoges, Service d'Oto-rhino-laryngologie (ORL) et chirurgie cervico-faciale [CHU Limoges], CHU Limoges
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Male
Cancer Research
medicine.medical_specialty
MESH: Rats
Rat model
Computed tomography
MESH: Rats
Sprague-Dawley
030218 nuclear medicine & medical imaging
Rats
Sprague-Dawley
MESH: Mouth Neoplasms
03 medical and health sciences
MESH: 4-Nitroquinoline-1-oxide
0302 clinical medicine
Fluorodeoxyglucose F18
MESH: Fluorodeoxyglucose F18
Carcinoma
Medicine
Animals
Radiology
Nuclear Medicine and imaging
MESH: Animals
Head and neck
medicine.diagnostic_test
business.industry
MESH: Carcinoma
Squamous Cell
medicine.disease
Head and neck squamous-cell carcinoma
4-Nitroquinoline-1-oxide
MESH: Male
MESH: Positron-Emission Tomography
3. Good health
Rats
MESH: Head and Neck Neoplasms
Oncology
Positron emission tomography
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Positron-Emission Tomography
Carcinoma
Squamous Cell
Fdg pet ct
Mouth Neoplasms
Radiology
Tomography
business
Tomography
X-Ray Computed
MESH: Tomography
X-Ray Computed
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Zdroj: Molecular Imaging and Biology
Molecular Imaging and Biology, Springer Verlag, 2009, 11 (2), pp.88-93. ⟨10.1007/s11307-008-0183-y⟩
ISSN: 1536-1632
DOI: 10.1007/s11307-008-0183-y⟩
Popis: ERMA; International audience; PURPOSE: The aim of this study was to demonstrate the ability to use human clinical positron emission tomography/computed tomography (PET/CT) to detect and investigate head and neck cancers chemically induced by 4-nitroquinoline-1-oxide (4-NQO) in a rat model. STUDY DESIGN: The study design was prospective animal research. PROCEDURES: A head and neck squamous cell carcinoma was established in 20 immunocompetent rats, who drank a 4-NQO solution during 16 weeks. 2-Deoxy-2-[F-18]fluoro-D: -glucose (FDG)-PET/CT was performed for five of them, 34 weeks after the start of the experiment to characterize the tumors. A day following the FDG-PET/CT, rats were euthanized and pathological features were evaluated by hematoxylin-eosin staining. RESULTS: All rats had head and neck tumor at various locations at 34 weeks. Among the five rats selected for having FDG-PET/CT, the clinical examination detected exophytic tumors grown in the oral cavity for three of them (one on the inferior lip, one on the hard palate, and one on the internal side of the cheek). FDG-PET/CT confirmed the presence of those tumors and detected ones located on the base of tongue for three of them. Tumor extensions were characterized and tumor metabolic volumes were measured. The smallest lesion detected measured 3 x 3 x 4 mm. Pathologic examination using hematoxylin-eosin staining confirmed squamous cell carcinoma. CONCLUSIONS: This study demonstrated that FDG-PET/CT is a feasible examination to detect occult primary tumors in rat models. It is useful to follow tumor progression and evaluate therapeutics efficacy.
Databáze: OpenAIRE
Externí odkaz: