Papillary tissue fragments in cervicovaginal (Pap) smears: Cytomorphologic characteristics and clinicopathologic significance
| Autor: | M.P.H. Lisa Marie Stoll M.D., Michael W. Johnson, Syed Z. Ali |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Cell Nucleus Shape Pathology medicine.medical_specialty Histology Genital Neoplasms Female Malignancy Pathology and Forensic Medicine Cytology medicine Atypia Carcinoma Humans Cell Shape Aged Aged 80 and over Vaginal Smears Pap smears business.industry Epithelial Cells General Medicine Papanicolaou Test Middle Aged medicine.disease Chromatin Genital neoplasm Adenocarcinoma Female business Follow-Up Studies |
| Zdroj: | Diagnostic Cytopathology. 39:657-662 |
| ISSN: | 8755-1039 |
| Popis: | Papillary epithelial fragments (PEFs) are a rarely described architectural feature in cervicovaginal (Pap) smears. Morphologically, PEFs often consist of small, finely branching glandular tissue fragments with varying cytomorphology. This study identified 21 Pap smears (1978–2009) containing PEFs to determine the clinicopathologic significance of such findings. Patients ranged in age from 36 to 81 years (mean, 54 years). The Pap smear diagnoses consisted of 48% overt malignant neoplasms, 24% atypical fragments, and 28% benign entities. The papillary fragments featured a range of cytomorphologies consisting of benign features, mild to marked atypia, and overt malignancy. PEFs were more commonly found (57%) in specimens from patients with significant pathologic outcomes. Hence, the presence of PEFs in a Pap smear should raise concern for a neoplastic process. In smears displaying atypical to malignant cytomorphologic features recommendations for further clinical work-up and/or tissue studies should be made. Diagn. Cytopathol. 2010. © 2010 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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